Caffeine is a central nervous system (CNS) stimulate and a addicting drug. When the central nervous system is stimulated it sends nerve impulses to the hypothalamus of the brain. The hypothalamus governs the releasing of 8 important hormones by the pituitary gland, also controls body temperature, our hunger and thirst, our sexual behavior and reproduction, emotional responses and our circadian rhythm. The circadian rhythm is our bodies daily cycles in our physiological state.
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When the hypothalamus receives these nerve impulses the brain secrets corticotropin-releasing hormone (CRH). (“Abnormally high levels of CRH have been found in the cerebrospinal fluid of people who have committed suicide.”) This hormone is carried to the pituitary gland by the portal system, which is located at the base of the brain. The CRH stimulates the anterior pituitary, resulting in the secretion of adrenocorticotropic hormone (ACTH). The ACTH is carried by the blood to the adrenal cortex. When the ACTH arrives at the adrenal gland through the blood, ACTH stimulates the adrenal gland in producing and secreting cortisol along with adrenaline. (ACTH is stopped and inhibited when cortisol purpose is accomplished and gets feedback.)
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So for cortisol to be produced it takes the central nervous system, the hypothalamus, the pituitary gland and, finally, the adrenal gland, where cortisol is produced. Four parts of the body are involved. And the manufacturing of two hormones: corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH), plus the nerve impulses that initiated this process.
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